Motilité structurale

Membres de l’équipe

Anne Houdusse, PhD

Houdusse

Anne Houdusse Directeur de recherche CNRS Equipe Houdusse Chef d'équipe Tél : Retour à la liste

Carrière

DR1 CNRS, Habilitée à diriger des Recherches
Membre du Comité de Programme « Sciences de la vie / Santé » du synchrotron SOLEIL.
Membre du Conseil scientifique du département Sciences du vivant du CNRS (08/06-10/10)
2004-2009 DR2 CNRS
Novembre, 2003 Responsable senior de l'équipe « Motilité Structurale » au sein de l'UMR 144 - Institut Curie/CNRS.
2004 Habilitation à diriger des recherches - Paris V
Octobre, 1999 Responsable d'une jeune équipe ATIPE - Institut Curie/CNRS.
Janvier, 1999 Chargé de Recherche Première classe au C.N.R.S. France.
1992-1998 - Post-doc dans le laboratoire de Carolyn COHEN, Brandeis University - USA.
1992 PhD in Protein Crystallography - University Paris XI / Pasteur Institute
1989 Agrégation (Competition to teach Chemistry) - ENS ULM in Chemistry
1988 DEA in Protein Crystallography - University Paris XI / Pasteur Institute
1987 Master in Chemistry - Ecole Normale Supérieure ULM - Paris


Distinctions

2013 Membre EMBO
2013 Médaille d'Argent CNRS
2010 Award winner for one of the three subventions of the Simone and Cino del Duca Foundation
2009 EMBO/FEBS Women in science Award
2005 FEBS Award : Federation of Biochemical Societies' Anniversary Prize for outstanding achievement in the field of Structural Biology.
2004 CNRS Bronze medal winner (given to recognize a researcher's first work, which makes that person a specialist with talent in a particular field)
1998 Award winner for the ATIP Competition organized by the CNRS for the establishment of young group leaders
1994-1995 Long-term Research Fellowship from HFSPO
1993 Long-term Research Fellowship from EMBO
1986 Admission to Ecole Normale Supérieure ULM - Paris

Publications clés

Année de publication : 2018

Julien Robert-Paganin, Daniel Auguin, Anne Houdusse (2018 Oct 3)

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition.

Nature communications : 4019 : DOI : 10.1038/s41467-018-06191-4
Florian Blanc, Tatiana Isabet, Hannah Benisty, H Lee Sweeney, Marco Cecchini, Anne Houdusse (2018 May 31)

An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics.

Proceedings of the National Academy of Sciences of the United States of America : 6213-6218 : DOI : 10.1073/pnas.1711512115

Année de publication : 2017

Stéphanie Miserey-Lenkei, Hugo Bousquet, Olena Pylypenko, Sabine Bardin, Ariane Dimitrov, Gaëlle Bressanelli, Raja Bonifay, Vincent Fraisier, Catherine Guillou, Cécile Bougeret, Anne Houdusse, Arnaud Echard, Bruno Goud (2017 Nov 3)

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions.

Nature communications : 1254 : DOI : 10.1038/s41467-017-01266-0
Vicente J Planelles-Herrero, James J Hartman, Julien Robert-Paganin, Fady I Malik, Anne Houdusse (2017 Aug 5)

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.

Nature communications : 190 : DOI : 10.1038/s41467-017-00176-5
I-Mei Yu, Vicente J Planelles-Herrero, Yannick Sourigues, Dihia Moussaoui, Helena Sirkia, Carlos Kikuti, David Stroebel, Margaret A Titus, Anne Houdusse (2017 Jun 30)

Myosin 7 and its adaptors link cadherins to actin.

Nature communications : 15864 : DOI : 10.1038/ncomms15864

Année de publication : 2016

Sirigu S, Hartman J, Planelles-Herrero VJ, Ropars V, Clancy S, Wang X, Chuang G, Qian X, Lu P-P, Barrett E, Rudolph K, Royer C, Morgan B, Stura EA, Malik FI, Houdusse A (2016 Nov 4)

Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.

Proceedings of the National Academy of Sciences of the United States of America : 201609342 : DOI : 10.1073/pnas.1609342113
Anne Houdusse, H Lee Sweeney (2016 Oct 9)

How Myosin Generates Force on Actin Filaments.

Trends in biochemical sciences : DOI : S0968-0004(16)30152-9

Année de publication : 2015

Paola Llinas, Tatiana Isabet, Lin Song, Virginie Ropars, Bin Zong, Hannah Benisty, Serena Sirigu, Carl Morris, Carlos Kikuti, Dan Safer, H Lee Sweeney, Anne Houdusse (2015 May 5)

How actin initiates the motor activity of Myosin.

Developmental cell : 401-12 : DOI : 10.1016/j.devcel.2015.03.025

Année de publication : 2010

H Lee Sweeney, Anne Houdusse (2010 May 19)

Myosin VI rewrites the rules for myosin motors.

Cell : 573-82 : DOI : 10.1016/j.cell.2010.04.028
H Lee Sweeney, Anne Houdusse (2010 Mar 3)

Structural and functional insights into the Myosin motor mechanism.

Annual review of biophysics : 539-57 : DOI : 10.1146/annurev.biophys.050708.133751

Année de publication : 2005

Julie Ménétrey, Amel Bahloul, Amber L Wells, Christopher M Yengo, Carl A Morris, H Lee Sweeney, Anne Houdusse (2005 Feb 1)

The structure of the myosin VI motor reveals the mechanism of directionality reversal.

Nature : 779-85