Membranes et fonctions cellulaires

Membres de l’équipe

Feng-Ching Tsai

Feng

Feng-Ching Tsai CNRS Researcher Equipe Bassereau Responsable de projet Tél :

Research Gate
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My personal website https://fctsai.com/

Google scholar https://scholar.google.ch/citations?user=EAafgAQAAAAJ&hl=en

ORCID https://orcid.org/0000-0002-6869-5254

 

Brief biography

After initially trained as a physicist, followed by a PhD in soft matter biophysics, and a postdoc in cell biology and membrane biophysics, I was recruited by CNRS as a permanent researcher in 2019.

Since 2019                    CNRS researcher (CRCN), Institut Curie, Paris, France

2014 – 2019                Postdoc in the groups of Dr. P. Bassereau and Dr. B. Goud, Institut Curie, Paris, France. (supported by EMBO and Marie Curie fellowships)

2009 – 2014               PhD thesis Cytoskeletal organization in biomimetic liposomes

Supervisor: Prof. G. Koenderink, AMOLF, the Netherlands

2007 – 2009                    Research Assistant. Topic: Actin-driven membrane waves in living cells

Supervisor: Prof. Chau-Hwang Lee, Academia Sinica, Taiwan

2005 – 2007                    Master thesis Physics of adsorption induced endocytosis

Supervisor: Prof. Hsuan-Yi Chen, National Central University, Taiwan

2001 – 2005                    Bachelor, Department of Physics, National Changhua University of Education, Taiwan

 

Current research focus

My current research aims to reveal physical mechanisms underlying actin-driven membrane reshaping in membrane trafficking and protrusion formation in cells.

To this end, I use principles and tools of physics, and bottom-up approaches – in vitro reconstitution systems composed of model membranes and purified proteins.

If you are interested in joining our research team as a postdoc, undergraduate or graduate student, please feel free to contact me!

 

Actin filaments are recruited to the membrane of a giant unilamellar vesicle (GUVs) via actin-membrane linker ezrin. Maximum intensity projection is shown. Green: actin. Scale bar, 5 μm.

 

 

 

 

 

 

Inward membrane protrusions induced by the I-BAR domain of IRSp53 on GUVs. Green: I-BAR domain, magenta: membranes. Scale bar, 5 μm.

 

 

 

 

 

 

Publications clés

Année de publication : 2019

Elena Beltrán-Heredia, Feng-Ching Tsai, Samuel Salinas-Almaguer, Francisco J. Cao*, Patricia Bassereau*, Francisco Monroy* (2019 Jun 20)

Membrane curvature induces cardiolipin sorting.

Communications Biology : 2 : 225 : DOI : 10.1038/s42003-019-0471-x
Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S*, Bertin A* (2019 Jan 24)

Membrane reshaping by micrometric curvature sensitive septin filaments

Nature communications : DOI : 10.1038/s41467-019-08344-5

Année de publication : 2018

Arthur Charles-Orszag, Feng-Ching Tsai, Daria Bonazzi, Valeria Manriquez, Martin Sachse, Adeline Mallet, Audrey Salles, Keira Melican, Ralitza Staneva, Aurélie Bertin, Corinne Millien, Sylvie Goussard, Pierre Lafaye, Spencer Shorte, Matthieu Piel, Jacomine Krijnse-Locker, Françoise Brochard-Wyart, Patricia Bassereau, Guillaume Duménil (2018 Oct 27)

Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting.

Nature communications : 4450 : DOI : 10.1038/s41467-018-06948-x
Feng-Ching Tsai*, Aurelie Bertin*, Hugo Bousquet, John Manzi, Yosuke Senju, Meng-Chen Tsai, Laura Picas, Stephanie Miserey-Lenkei, Pekka Lappalainen, Emmanuel Lemichez, Evelyne Coudrier*, Patricia Bassereau* (2018 Sep 30)

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner.

elife : 7 : e37262 : DOI : 10.7554/eLife.37262

Année de publication : 2015

Feng-Ching Tsai, Gijsje Hendrika Koenderink (2015 Sep 23)

Shape control of lipid bilayer membranes by confined actin bundles

Soft Matter : 11 : DOI : 10.1039/C5SM01583A

Année de publication : October 8, 2013

Kevin Carvalho, Feng-Ching Tsai, Edouard Lees, Raphaël Voituriez, Gijsje H. Koenderink, and Cecile Sykes (2013 Oct 8)

Cell-sized liposomes reveal how actin-myosin cortical tension drives shape change

Proceedings of the National Academy of Sciences of the United States of America : 110 : DOI : 10.1073/pnas.1221524110