Postdoctoral position available in Institut Curie, Paris France in the team of Raphael
Rodriguez, at Institut Curie, Paris.
Starting date: 2018
Duration: 1 year + 2 years renewal upon success
Title of the research program: Targeting STING with small molecules in innate immunity
Scientific background for the project: The presence of DNA in the cytosol of cells is a universal process of innate immune defense against microbes, cancer, infections and is also implicated in aging and auto-immunities. STING is a receptor for nature small cyclic di-nucleotides (c-di-GMP, cdi-AMP, cGAMP and related compounds) that plays a crucial role in these processes. Interestingly, STING is controlled by two parallel checkpoints, the binding to di-nucleotides and the translocation of the protein from the ER to a Golgi-related compartment. The goal of the project is to elucidate how activation of STING is regulated by these checkpoints using small molecules. Specific objectives of the research program: The applicant will develop small molecule probes derived from STING agonists to visualize the endogenous localization and properties of STING in cells. The candidate will work in close collaboration with talented teams of cell biologists led by Franck Perez and immunologists led by Nicolas Manel. The application will greatly benefit from relevant immunological and cellular biological assays that are already established in the partner labs. The team of Raphaël Rodriguez has established expertise in chemical labelling of biologically-active small molecules in cells that will be at the core of this research. For more information click here.