Trafic endocytique et ciblage intracellulaire

Membres de l’équipe

Johannes Ludger , PhD

image001Ludger

Ludger Johannes Directeur d'unité, DR1 INSERM Equipe Johannes Directeur d'unité, DR1 INSERM Tél : Retour à la liste

Publications clés

Année de publication : 2017

Mijo Simunovic, Jean-Baptiste Manneville, Henri-François Renard, Emma Evergren, Krishnan Raghunathan, Dhiraj Bhatia, Anne K. Kenworthy, Gregory A. Voth, Jacques Prost, Harvey T. McMahon, Ludger Johannes, Patricia Bassereau, Andrew Callan-Jones (2017 Jun 22)

Friction mediates scission of tubular membranes scaffolded by BAR proteins

CellCell : 170 : 172-184 : DOI : 10.1016/j.cell.2017.05.047

Année de publication : 2016

Daniela Chmiest, Nanaocha Sharma, Natacha Zanin, Christine Viaris de Lesegno, Massiullah Shafaq-Zadah, Vonick Sibut, Florent Dingli, Philippe Hupé, Stephan Wilmes, Jacob Piehler, Damarys Loew, Ludger Johannes, Gideon Schreiber, Christophe Lamaze (2016 Dec 6)

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.

Nature communications : 13476 : DOI : 10.1038/ncomms13476
Mijo Simunovic, Emma Evergren, Ivan Golushko, Coline Prévost, Henri-François Renard, Ludger Johannes, Harvey T McMahon, Vladimir Lorman, Gregory A Voth, Patricia Bassereau (2016 Oct 4)

How curvature-generating proteins build scaffolds on membrane nanotubes.

Proceedings of the National Academy of Sciences of the United States of America : 113 : DOI : 10.1073/pnas.1606943113
Cédric M Blouin, Yannick Hamon, Pauline Gonnord, Cédric Boularan, Jérémy Kagan, Christine Viaris de Lesegno, Richard Ruez, Sébastien Mailfert, Nicolas Bertaux, Damarys Loew, Christian Wunder, Ludger Johannes, Guillaume Vogt, Francesc-Xabier Contreras, Didier Marguet, Jean-Laurent Casanova, Céline Galès, Hai-Tao He, Christophe Lamaze (2016 Aug 9)

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.

Cell : 920-34 : DOI : 10.1016/j.cell.2016.07.003

Année de publication : 2015

Henri-François Renard, Mijo Simunovic, Joël Lemière, Emmanuel Boucrot, Maria Daniela Garcia-Castillo, Senthil Arumugam, Valérie Chambon, Christophe Lamaze, Christian Wunder, Anne K Kenworthy, Anne A Schmidt, Harvey T McMahon, Cécile Sykes, Patricia Bassereau, Ludger Johannes (2015 Jan 22)

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis.

Nature : 493-6 : DOI : 10.1038/nature14064

Année de publication : 2013

Emmanuelle Girard, Daniela Chmiest, Natalie Fournier, Ludger Johannes, Jean-Louis Paul, Benoît Vedie, Christophe Lamaze (2013 Sep 17)

Rab7 is functionally required for selective cargo sorting at the early endosome.

Traffic (Copenhagen, Denmark) : 309-26 : DOI : 10.1111/tra.12143
Federico Sandoval, Magali Terme, Mevyn Nizard, Cécile Badoual, Michel-Francis Bureau, Ludovic Freyburger, Olivier Clement, Elie Marcheteau, Alain Gey, Guillaume Fraisse, Cécilia Bouguin, Nathalie Merillon, Estelle Dransart, Thi Tran, Françoise Quintin-Colonna, Gwennhael Autret, Marine Thiebaud, Muhammad Suleman, Muhammed Suleman, Sabine Riffault, Tzyy-Choou Wu, Odile Launay, Claire Danel, Julien Taieb, Jennifer Richardson, Laurence Zitvogel, Wolf H Fridman, Ludger Johannes, Eric Tartour (2013 Feb 15)

Mucosal imprinting of vaccine-induced CD8⁺ T cells is crucial to inhibit the growth of mucosal tumors.

Science translational medicine : 172ra20 : DOI : 10.1126/scitranslmed.3004888

Année de publication : 2012

Giovanni D'Angelo, Takefumi Uemura, Chia-Chen Chuang, Elena Polishchuk, Michele Santoro, Henna Ohvo-Rekilä, Takashi Sato, Giuseppe Di Tullio, Antonio Varriale, Sabato D'Auria, Tiziana Daniele, Fabrizio Capuani, Ludger Johannes, Peter Mattjus, Maria Monti, Piero Pucci, Roger L Williams, John E Burke, Frances M Platt, Akihiro Harada, Maria Antonietta De Matteis (2012 Jun 21)

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi.

Nature : 116-20 : DOI : 10.1038/nature12423

Année de publication : 2010

Bidisha Sinha, Darius Köster, Richard Ruez, Pauline Gonnord, Michele Bastiani, Daniel Abankwa, Radu V Stan, Gillian Butler-Browne, Benoit Vedie, Ludger Johannes, Nobuhiro Morone, Robert G Parton, Graça Raposo, Pierre Sens, Christophe Lamaze, Pierre Nassoy (2010 Jan 7)

Cells respond to mechanical stress by rapid disassembly of caveolae.

Cell : 402-13 : DOI : 10.1016/j.cell.2010.12.031

Année de publication : 2009

Bahne Stechmann, Siau-Kun Bai, Emilie Gobbo, Roman Lopez, Goulven Merer, Suzy Pinchard, Laetitia Panigai, Danièle Tenza, Graça Raposo, Bruno Beaumelle, Didier Sauvaire, Daniel Gillet, Ludger Johannes, Julien Barbier (2009 Jul 30)

Inhibition of retrograde transport protects mice from lethal ricin challenge.

Cell : 231-42 : DOI : 10.1016/j.cell.2010.01.043
Julie Claudinon, Pauline Gonnord, Emilie Beslard, Marta Marchetti, Keith Mitchell, Cédric Boularan, Ludger Johannes, Pierre Eid, Christophe Lamaze (2009 Jun 26)

Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha.

The Journal of biological chemistry : 24328-40 : DOI : 10.1074/jbc.M109.021915
Winfried Römer, Léa-Laetitia Pontani, Benoît Sorre, Carles Rentero, Ludwig Berland, Valérie Chambon, Christophe Lamaze, Patricia Bassereau, Cécile Sykes, Katharina Gaus, Ludger Johannes (2009 Feb 19)

Actin dynamics drive membrane reorganization and scission in clathrin-independent endocytosis.

Cell : 540-53 : DOI : 10.1016/j.cell.2010.01.010

Année de publication : 2007

Winfried Römer, Ludwig Berland, Valérie Chambon, Katharina Gaus, Barbara Windschiegl, Danièle Tenza, Mohamed R E Aly, Vincent Fraisier, Jean-Claude Florent, David Perrais, Christophe Lamaze, Graça Raposo, Claudia Steinem, Pierre Sens, Patricia Bassereau, Ludger Johannes (2007 Aug 15)

Shiga toxin induces tubular membrane invaginations for its uptake into cells.

Nature : 670-5

Année de publication : 2006

Marta Marchetti, Marie-Noelle Monier, Alexandre Fradagrada, Keith Mitchell, Florence Baychelier, Pierre Eid, Ludger Johannes, Christophe Lamaze (2006 Apr 19)

Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors.

Molecular biology of the cell : 2896-909