UMR3666/U1143 – Chimie biologique des membranes et ciblage thérapeutique

Brevets

2016. Visual detection of platinated DNA lesions from a clickable cisplatin probe used as diagnostic tool or to identify synergistic treatments. Emmanouil Zacharioudakis, Lavaniya Kunalingam, Poonam Agarwal, Alexandra Bartoli, Kyle M. Miller, Raphaël Rodriguez. PCT/EP2016/081166

2016. Total cellular iron as a marker of cancer stem cells and uses thereof. Trang Mai, Ahmed Hamaï, Maryam Mehrpour, Raphaël Rodriguez. EP16305266.5

2015. Nitrogen-containing analogs of Salinomycin, synthesis and use against cancer stem cells and malaria. Trang Mai, Antje Hienzsch, Ahmed Hamaï, Maryam Mehrpour, Raphaël Rodriguez. PCT/EP2015/070975

2015. Method for preparing marmycin a and analogues thereof, and also uses thereof. Tatiana Cañeque, Filipe Gomes, Trang Thi Mai, Giovanni Maestri, Max Malacria, Raphaël Rodriguez. WO2016034559 A1

2014. KAT inhibitors for the treatment of laminopathies, ageing and cancer. Delphine Larrieu, Sébastien Britton, Raphaël Rodriguez, Stephen P. Jackson. PCT/GB2015/051040

2012. Nouveaux composes ayant une activité protectrice vis-à-vis de toxines au mode d’action intracellulaire. European Patent 12306297.8.2012. Conjugates of the B subunit of Shiga toxin for anticancer therapies. Patent PCT/EP2013/075731.

2012. Conjugates of the B subunit of Shiga toxin for use as contrasting agents for imaging and therapy. Patent PCT/EP2013/075712.

2011. Compositions having means for targeting at least one antigen to dendritic cells. Patent P11305959.6.

2009. Inhibitors of the Shiga toxin trafficking through the retrograde pathway. Patent WO 2009/153665. Granted in Europe and the US.

2007. Shiga toxin B-subunit/Chemotherapeutics conjugates. Patent US 11 958 576.

2006. Compositions using the B-subunit of Shiga toxin as a means of stimulating NKT cells. Patent WO

2008080926; extension Europe, USA, Japan, Canada; delivered in the US.

2002. Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to Gb3 expressing tumors. Patent EP 02 291 965.5; delivered in the US, Europe, Japan.

2001. Universal carrier for targeting molecules to Gb3 receptor expressing cells. Patent WO 02/060937; delivered in Europe, Japan, USA, Canada.

1998. Verotoxin B-subunit for immunization. Patent WO 99/59627; delivered in Europe, Japan, USA, Canada.

1997. Chimeric polypeptide comprising the fragment B of Shiga toxin and peptides of therapeutic interest. Patent WO 99/03881; delivered in Australia, Europe, Hong-Kong, Japan, France, USA, Canada.