Chimie et Biologie du Cancer

Publications de l’équipe

Année de publication : 2005

Raphaël Rodriguez, John E Moses, Robert M Adlington, Jack E Baldwin (2005 Sep 21)

A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of the benzopyran derived natural products (+/-)-lucidene and (+/-)-alboatrin.

Organic & biomolecular chemistry : 3488-95 En savoir plus
Résumé

Lucidene and alboatrin are complex benzopyran derived natural products. A key step in their biogenesis may involve a hetero Diels-Alder cycloaddition between an o-quinone methide intermediate with a simple, or activated tri-substituted olefin. Experimental evidence is provided to support this hypothesis, with the biomimetic synthesis of both (+/-)-lucidene and (+/-)-alboatrin successfully achieved using a new and efficient method for o-quinone methide generation.

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John E Moses, Robert M Adlington, Raphaël Rodriguez, Serena J Eade, Jack E Baldwin (2005 Mar 26)

Biomimetic synthesis of (+/-)-9,10-deoxytridachione.

Chemical communications (Cambridge, England) : 1687-9 En savoir plus
Résumé

A tandem Suzuki-coupling/electrocyclisation reaction sequence was employed for the biomimetic synthesis of (+/-)-9,10-deoxytridachione.

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Année de publication : 2004

Raphaël Rodriguez, Robert M Adlington, John E Moses, Andrew Cowley, Jack E Baldwin (2004 Sep 25)

A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of (+/-)-Alboatrin.

Organic letters : 3617-9 En savoir plus
Résumé

[reaction: see text] A new and efficient method for o-quinone methide intermediate generation from o-methyleneacetoxy-phenols has been developed and applied to the biomimetic synthesis of (+/-)-Alboatrin.

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