Chimie et Biologie du Cancer

Membres de l’équipe

Sebastian Müller, PhD, CRCN, INSERM

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Sebastian Müller Equipe Rodriguez Senior Scientist Tél :

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Curriculum Vitae


Employment

2019+ Senior Researcher, INSERM, CRCN, Chemical Cell Biology Group, Institut Curie/ France

2016-2018 SeniorPostdoctoral Researcher; Chemical Cell Biology Group, Institut Curie/ France

2011-2015 Postdoctoral Researcher; Nuclear Dynamics, Institut Curie/ France, Dr. Geneviève Almouzni;

Education

2006-2010 Ph.D. in Chemical Biology ; Cambridge University, UK, Prof. Shankar Balasubramanian

2002-2006 M.Sci. in Biology & Chemistry; Durham University, Dr. Gareth Williams & Dr. Adam Benham

2001-2002 Cambridge Certificate of Proficiency in English; Lincoln College, UK

1999-2001 Baccalaureate/ Abitur: 1.2; Leipzig, Evangel. Schulzentrum, Germany

1999 General Certificate of Standard Education; Helensburgh, Lomond School, UK

Additional Work Experience

2009+ Scientific Reviewer; Nature, Cell, J Am Chem Soc & Angew Chem, Genes & Dev, Elife and others

2003-2006 Researcher; Durham University, School of Biomedical Sciences, UK Dr. Rumaisa Bashir

2004  Field Assistant; Abisko Research Station, Sweden Dr. Robert Baxter

Language Skills

German: Native; English: Bilingual; French: Fluent

Awards

2013-2015 Postdoctoral Fellowship, Fondation de la Récherche Médicale, France

2011-2013 Postdoctoral Fellowship, Marie Curie Actions FP7 ITN network, European Funding

2006-2011 Doctoral Fellowship, Cancer Research United Kingdom, UK

1998 Lomond Scholarship – School exchange to Scotland for 6 months


Publications

Google Scholar.

# equal contribution; * corresponding author

(27) S. Müller; A. Versini, F. Sindikubwabo, G. Belthier, S. Niyomchon, J. Pannequin, L. Grimaud, T. Cañeque, R. Rodriguez. Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells. PLOS One, 13, e0206764

(26) G. Gentric, Y. Kieffer, O. Goundiam, V. Mieulet, C. Bonneau, F. Nemati, I. Hurbain, G. Raposo, T. Popova, M.-H. Stern, V. Lallemand-Breitenbach, A. Vincent-Salomon, H. de Thé, R. Rossignol,  S. Müller, T. Cañeque,  R. Rodriguez and F. Mechta-Grigoriou. PML-dependent metabolic heterogeneity enhances chemosensitivity in human ovarian cancers. Cell Metabolism2018, 156–173

(25) A. Versini, L. Saier, F. Sindikubwabo, S. Müller, T. Cañeque, R. Rodriguez. Chemical biology of salinomycin. Tetrahedron, 2018, 74, 5585-5614

(24) T. Cañeque#S. Müller#, R. Rodriguez. Visualizing biologically active small molecules in cells using click chemistry. Nature Rev. Chem2018, 2, 202-215

(23) T. Cañeque, S. Müller, A. Lafon, F. Sindikubwabo, A. Versini, L. Saier, M. Barutaut, C. Gaillet, R. Rodriguez. Reprogramming the reactivity of iron in cancer stem cells. Comptes Rendus Chimie, 2018, 21, 704-708

(22) A. Hamaï, T. Cañeque, S. Müller, T. T. Mai,A. Hienzsch, C. Ginestier, E. Charafe-Jauffret, P. Codogno, M. Mehrpour, R. Rodriguez. An iron hand over cancer stem cells. Autophagy, 2017, 13,1465-1466

(21) T. T. Mai, A. Hamaï, A. Hienzsch, T. Cañeque, S. Müller, J. Wicinski, O. Cabaud, C. Leroy, A. David, V. Acevedo, A. Ryo, C. Ginestier, D. Birnbaum, E. Charafe-Jauffret, P. Codogno, M. Mehrpour, R. Rodriguez. Salinomycin kills cancer stem cells by sequestering iron in lysosomes. Nature Chem, 2017, 9,1025–1033, Highlighted in chemical & engineering news

(21) S. Müller*, DNA damage-inducing compounds: unravelling their pleiotropic effects using high throughput sequencing. Curr Med Chem, 2017, 24

(19) S. Müller, G. Almouzni. Centromeric chromatin dynamics during the cell cycle. Nature Reviews Genetics, 2017, 18, 192–208

(18) S. Müller, T. Cañeque, V Acevedo, R. Rodriguez. Targeting cancer stem cells with small molecules. invited for special issue on Wolf prize of Chemistry 2016,  Israel J of Chemistry, 2017; DOI: 10.1002/ijch.201600109

(17) E. Zacharioudakis, R. Custodio, T. Cañeque*, S. Müller, Ana M. Cuadro, Juan J. Vaquero, R. Rodriguez. Quinolizinium as a new fluorescent lysosomotropic probe. Bioorg Med Chem Lett, 2017, 27, 203-207

(16) L. Prendergast, S. Müller#, Y. Liu#, H. Huang, F. Dingli, D. Loew, I. Vassias, R. Amignacco, D.J. Patel, K.F. Sullivan, G. Almouzni. The CENP-T-CENP-W complex is a binding partner of the H2A-H2B chaperone FACT. Genes & Dev, 2016, 30, 1313-1326

(15) S. Müller*, G-quadruplex interacting small molecules and their biological implications, Book chapter, “G-Quadruplex Structures, Formation and Roles in Biology”, 2016, Nova Science Publishers

(14) S. Müller, D. Filipescu, G. Almouzni. Developmental roles of histone H3 variants and their chaperones. Book chapter in “The Functional Nucleus”, 2016, Springer Verlag

(13) H. Tachiwana#, S. Müller#, J. Blümer, K. Klare, A. Musacchio G. Almouzni. HJURP involvement in de novo CenH3CENP-A and CENP-C recruitment. Cell Rep, 2015, 11, 1-11

(12) S. Müller, R. Montes de Oca, N. Lacoste, F. Dingli, D. Loew, G. Almouzni. Phosphorylation and DNA-binding of HJURP determine its centromeric recruitment and function in CenH3CENP-A loading. Cell Rep, 2014, 8, 190-203

(11) D. Filipescu#, S. Müller#, G. Almouzni. Histone H3 variants and their chaperones in development and disease: contributing to epigenetic control. Ann Rev Cell Dev Biol, 2014, 30, 615-646

(10) S. Müller, K. Laxmi-Reddy, R. Rodriguez, P. V. Jena, B. Baptiste, Z. Dong, F. Godde, T. Ha, S. Balasubramanian, I. Huc. Targeting DNA G-quadruplexes with helical small molecules. ChemBioChem, 2014, 15, 2563-2570

(9) S. Müller*, R. Rodriguez. G-quadruplex interacting small molecules and drugs: from bench toward bedside. Expert Rev Clin Pharmacol, 2014, 7, 663-679

(8) S. Müller, G. Almouzni. A network of players in H3 histone variant deposition and maintenance at centromeres. BBA Gene Reg Mech, 2014, 1839, pp. 241-250

(7) S. Müller, D.A. Sanders, M. Di Antonio, S. Matsis, J.-F. Riou, R. Rodriguez, S. Balasubramanian. Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem, 2012, 10, 6537-6546

(6) S. Müller#, S. Kumari#, R. Rodriguez and S. Balasubramanian. Small-molecule-mediated G-quadruplex isolation from human cells. Nature Chem, 2010, 2, 1095-1098; Highlight in F1000

(5) M. Bejugam, M. Gunaratnam, S. Müller, D. A. Sanders, S. Sewitz, J. A. Fletcher, S. Neidle, S. Balasubramanian. Targeting the c-Kit promoter G-quadruplexes with 6-substituted indenoisoquinolines. ACS Med Chem Let, 2010, 1, 306-310

(4) S. Müller, G. D. Pantos, R. Rodriguez, S. Balasubramanian. Controlled-folding of a small molecule modulates DNA G-quadruplex recognition. Chem Comm, 2009, 80-82

(3) R. Rodriguez, S. Müller, J. A. Yeoman, C. Trentesaux, J.-F. Riou, S. Balasubramanian. Novel small molecule that alters Shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc, 2008, 130, 15758-15759

(2) J. Jaiswal, G. Marlow, G. Summerill, I. Mahjneh, S. Müller, M. Hill, K. Miyake, H. Haase, L. Anderson, I. Richard, S. Kiuru-Enari, P. McNeil, S. Simon, R. Bashir. Patients with a non-dysferlin Miyoshi Myopathy have a novel membrane repair defect. Traffic, 2007, 8, 77-88

(1) J. Jaiswal, K. Miyake, G. Summerill, S. Müller, I. Mahjneh, F. Baas, M. Visser, P. McNeil, R. Bashir. Defective membrane repair in non-dysferlin Miyoshi myopathy. Neuromuscul Disord, 2005, 15, 692

Publications clés

Année de publication : 2019

G Gentric, Y Kieffer, V Mieulet, O Goundiam, C Bonneau, F Nemati, I Hurbain, G Raposo, T Popova, MH Stern, V Lallemand-Breitenbach, S Müller, T Cañeque, R Rodriguez, A Vincent-Salomon, H de Thé, R Rossignol, F Mechta-Grigoriou (2019 Jan 5)

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

Cell Metabolism

Année de publication : 2018

Tatiana Cañeque, Sebastian Müller, Raphaël Rodriguez (2018 Aug 15)

Visualizing biologically active small molecules in cells using click chemistry

Nature Rev. Chem.

Année de publication : 2017

Trang Thi Mai, Ahmed Hamaï, Antje Hienzsch, Tatiana Cañeque, Sebastian Müller, Julien Wicinski, Olivier Cabaud, Christine Leroy, Amandine David, Verónica Acevedo, Akihide Ryo, Christophe Genestier, Daniel Birnbaum, Emmanuelle Charafe-Jauffret, Patrice Codogno, Maryam Mehrpour, Raphaël Rodriguez (2017 May 15)

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Nature Chemistry : DOI : 10.1038/nchem.2778
Sebastian Müller (2017 Mar 1)

DNA damage-inducing compounds: unravelling their pleiotropic effects using high throughput sequencing

Curr Med Chem

Année de publication : 2016

Sebastian Müller, Geneviève Almouzni (2016 Dec 1)

Chromatin dynamics during the cell cycle at centromeres.

Nature Reviews Genetics : 192-208 : DOI : 10.1038/nrg.2016.157
Lisa Prendergast, Sebastian Müller, Yiwei Liu, Hongda Huang, Florent Dingli, Damarys Loew, Isabelle Vassias, Dinshaw J Patel, Kevin F Sullivan, Geneviève Almouzni (2016 Jun 11)

The CENP-T/-W complex is a binding partner of the histone chaperone FACT.

Genes & development : 1313-26 : DOI : 10.1101/gad.275073.115

Année de publication : 2015

Hiroaki Tachiwana, Sebastian Müller, Julia Blümer, Kerstin Klare, Andrea Musacchio, Geneviève Almouzni (2015 Apr 1)

HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.

Cell reports : 22-32 : DOI : 10.1016/j.celrep.2015.03.013

Année de publication : 2014

Dan Filipescu, Sebastian Müller, Geneviève Almouzni (2014 Oct 8)

Histone H3 variants and their chaperones during development and disease: contributing to epigenetic control.

Annual review of cell and developmental biology : 615-46 : DOI : 10.1146/annurev-cellbio-100913-013311
Sebastian Müller, Raphaël Rodriguez (2014 Aug 5)

G-quadruplex interacting small molecules and drugs: from bench toward bedside.

Expert review of clinical pharmacology : 663-79 : DOI : 10.1586/17512433.2014.945909
Sebastian Müller, Rocio Montes de Oca, Nicolas Lacoste, Florent Dingli, Damarys Loew, Geneviève Almouzni (2014 Apr 8)

Phosphorylation and DNA binding of HJURP determine its centromeric recruitment and function in CenH3(CENP-A) loading.

Cell reports : 190-203 : DOI : 10.1016/j.celrep.2014.06.002
Sebastian Müller, Geneviève Almouzni (2014 Jan 1)

A network of players in H3 histone variant deposition and maintenance at centromeres.

Biochimica et biophysica acta : 241-50 : DOI : 10.1016/j.bbagrm.2013.11.008

Année de publication : 2012

Sebastian Müller, Deborah A Sanders, Marco Di Antonio, Stephanos Matsis, Jean-François Riou, Raphaël Rodriguez, Shankar Balasubramanian (2012 Jul 14)

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells.

Organic & biomolecular chemistry : 6537-46 : DOI : 10.1039/c2ob25830g

Année de publication : 2010

Sebastian Müller, Sunita Kumari, Raphaël Rodriguez, Shankar Balasubramanian (2010 Apr 29)

Small-molecule-mediated G-quadruplex isolation from human cells.

Nature chemistry : 1095-8 : DOI : 10.1038/nchem.842