UMR3348 – Stress génotoxique et cancer

Publications de l’unité

Année de publication : 2018

Renaud Chabrier, Carsten Janke (2018 Mar 1)

The comeback of hand drawing in modern life sciences.

Nature reviews. Molecular cell biology : DOI : 10.1038/nrm.2017.126 En savoir plus
Résumé

Scientific manuscripts are full of images. Since the birth of the life sciences, these images were in a form of hand drawings, with great examples from da Vinci, Hooke, van Leeuwenhoek, Remak, Buffon, Bovery, Darwin, Huxley, Haeckel and Gray’s Anatomy to name a few. However, in the course of the past century, photographs and simplified schematics have gradually taken over as a way of illustrating scientific data and concepts, assuming that these are ‘accurate’ representations of the truth. Here, we argue for the importance of reviving the art of scientific drawings as a way of effectively communicating complex scientific ideas to both specialists and the general public.

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Jonathan Bond, Christine Tran Quang, Guillaume Hypolite, Mohamed Belhocine, Aurélie Bergon, Gaëlle Cordonnier, Jacques Ghysdael, Elizabeth Macintyre, Nicolas Boissel, Salvatore Spicuglia, Vahid Asnafi (2018 Mar 1)

Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome.

Molecular cancer research : MCR : DOI : 10.1158/1541-7786.MCR-17-0442 En savoir plus
Résumé

Leukemias are frequently characterized by the expression of oncogenic fusion chimeras that normally arise due to chromosomal rearrangements. Intergenically spliced chimeric RNAs (ISC) are transcribed in the absence of structural genomic changes, and aberrant ISC expression is now recognized as a potential driver of cancer. To better understand these potential oncogenic drivers, high-throughput RNA sequencing was performed on T-acute lymphoblastic leukemia (T-ALL) patient specimens (n = 24), and candidate T-ALL-related ISCs were identified (n = 55; a median of 4/patient). In-depth characterization of the NFATC3-PLA2G15 chimera, which was variably expressed in primary T-ALL, was performed. Functional assessment revealed that the fusion had lower activity than wild-type NFATC3 in vitro, and T-ALLs with elevated NFATC3-PLA2G15 levels had reduced transcription of canonical NFAT pathway genes in vivo Strikingly, high expression of the NFATC3-PLA2G15 chimera correlated with aggressive disease biology in murine patient-derived T-ALL xenografts, and poor prognosis in human T-ALL patients. Mol Cancer Res; 1-6. ©2018 AACR.

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Carla G Silva, Elise Peyre, Mohit H Adhikari, Sylvia Tielens, Sebastian Tanco, Petra Van Damme, Lorenza Magno, Nathalie Krusy, Gulistan Agirman, Maria M Magiera, Nicoletta Kessaris, Brigitte Malgrange, Annie Andrieux, Carsten Janke, Laurent Nguyen (2018 Feb 22)

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.

Cell : 1063-1078.e19 : DOI : 10.1016/j.cell.2018.01.031 En savoir plus
Résumé

Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers.

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Carsten Janke (2018 Feb 19)

A unified reviewing format for grant applications and evaluations.

EMBO reports : 187-188 : DOI : 10.15252/embr.201745611 En savoir plus
Résumé

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