Specific genomic alterations in high grade pulmonary neuroendocrine tumours with carcinoid morphology.

Jérôme Cros, Nathalie Théou-Anton, Valérie Gounant, Remy Nicolle, Cécile Reyes, Sarah Humez, Ségolène Hescot, Vincent Thomas de Montpréville, Serge Guyétant, Jean-Yves Scoazec, Alice Guyard, Louis de Mestier, Solenn Brosseau, Pierre Mordant, Yves Castier, David Gentien, Philippe Ruszniewski, Gérard Zalcman, Anne Couvelard, Aurélie Cazes (2020 Feb 5) Neuroendocrinology : DOI : 10.1159/000506292
Résumé

High grade lung neuroendocrine tumours with carcinoid morphology have been recently reported; they may represent the thoracic counterparts of grade 3 digestive neuroendocrine tumours. We aimed to study their genetic landscape including analysis of tumoral heterogeneity.