Better Efficacy of Synchrotron Spatially Microfractionated Radiation Therapy Than Uniform Radiation Therapy on Glioma.

Audrey Bouchet, Elke Bräuer-Krisch, Yolanda Prezado, Michèle El Atifi, Léonid Rogalev, Céline Le Clec'h, Jean Albert Laissue, Laurent Pelletier, Géraldine Le Duc (2016 Jun 22) International journal of radiation oncology, biology, physics : 1485-1494 : DOI : S0360-3016(16)30030-X

Synchrotron microbeam radiation therapy (MRT) is based on the spatial fractionation of the incident, highly focused synchrotron beam into arrays of parallel microbeams, typically a few tens of microns wide and depositing several hundred grays. This irradiation modality was shown to have a high therapeutic impact on tumors, especially in intracranial locations. However, mechanisms responsible for such a property are not fully understood.