Sebastian Amigorena is “Directeur de Recherche Classe Exceptionnelle” at CNRS, Director of the “Center of Immunotherapy for cancers” and the “Immune responses and cancer” Team at Institut Curie (Paris, France), included in the Immunology Department "Immunity and Cancer" that he created in 2003 and directed until March 2021.
Dr. Amigorena obtained a PhD in Biochemistry in 1990, and joined CNRS before doing a post-doctoral training at Yale School of Medecine (1992-1994). He returned to France in 1995 and started his team at Institut Curie (Paris, France).
Dr . Amigorena made groundbreaking contributions to immunology and cell biology, at every stage of his career. As a PhD student, he discovered ITIMs, a family of short amino acid motifs present in the cytosolic tails of numerous inhibitory immunoreceptors that play critical roles in the control of autoimmunity. As a postdoc, he identified specialized intracellular compartments, related to endosomes, where peptides are loaded on MHC molecules. As a group leader, he pioneered the field of antigen cross presentation, establishing the fundamental functional properties of phagosomes in mouse and human dendritic cells and showing how these specializations contribute to the initiation of adaptive immune responses by dendritic cells. Amigorena’s group also showed that regulatory T cells inhibit low avidity CD8+ T cells selectively, thus preventing autoimmune reactivity and optimizing the efficacy of effector and memory immune responses against non-self antigens. His findings modified our understanding of antigen presentation and T cell priming by dendritic cells, with applications in the fields of cancer immunotherapy and vaccination. Dr. Amigorena published over 200 original articles, including, as a co-first or co-last author, in Nature (4x), Science (3x), Cell (2x), Immunity (6x), Nature Immunology (4x), Nature Cell Biology (2x), and Journal of Experimental Medicine (6x).
Dr. Amigorena is a member of the French “Académie des Sciences” and an elected EMBO member since 2005. He received numerous national and international prices and awards, including the Silver Medal from CNRS (2004), the Research award from Fondation Bettencourt (2005), the Griffuel Prize from ARC (2007), the Alt Award from CRI, and twice the prestigious senior European Research Council (ERC) award (2008 and 2014), the award Claude Bernard from Paris City (2017). He became Knight of the French "Légion d'honneur" (2018). He co-directs the Labex (Investissements d’Avenir) DC-BIOL, awarded in 2012. He serves on numerous Editorial Boards and is a regular referee for major international journals (including as a reviewing editor in Science, since 2012). He mentored over 30 post docs and students. His international leadership is reflected by invitations to write reviews in the most influential journals and to speak, including as a Keynote Speaker, at over 100 international conferences.
Année de publication : 2020
Marianne Burbage, Sebastian Amigorena (2020 Aug 14)
Nicolas Gonzalo Núñez, Jimena Tosello Boari, Rodrigo Nalio Ramos, Wilfrid Richer, Nicolas Cagnard, Cyrill Dimitri Anderfuhren, Leticia Laura Niborski, Jeremy Bigot, Didier Meseure, Philippe De La Rochere, Maud Milder, Sophie Viel, Delphine Loirat, Louis Pérol, Anne Vincent-Salomon, Xavier Sastre-Garau, Becher Burkhard, Christine Sedlik, Olivier Lantz, Sebastian Amigorena, Eliane Piaggio (2020 Jul 1)
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients.
Andrés Alloatti, Derek C Rookhuizen, Leonel Joannas, Jean-Marie Carpier, Salvador Iborra, Joao G Magalhaes, Nader Yatim, Patrycja Kozik, David Sancho, Matthew L Albert, Sebastian Amigorena (2017 Jul 1)
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
Matias Ostrowski, Nuno B Carmo, Sophie Krumeich, Isabelle Fanget, Graça Raposo, Ariel Savina, Catarina F Moita, Kristine Schauer, Alistair N Hume, Rui P Freitas, Bruno Goud, Philippe Benaroch, Nir Hacohen, Mitsunori Fukuda, Claire Desnos, Miguel C Seabra, François Darchen, Sebastian Amigorena, Luis F Moita, Clotilde Thery (2009 Aug 14)
Rab27a and Rab27b control different steps of the exosome secretion pathway.