The main focus of the research done in my team at Institut curie is the use of theoretical approaches based on Physics to understand the organization and dynamics of living matter, particularly at the level of biological cells and cellular tissues. We are developing theoretical models using methods of statistical physics, non-linear dynamics and soft-matter physics, to improve our understanding of the principles governing the organization of cellular processes.
An important aspect of our work is to work in close collaboration with experimental physicists and biologists, at Institut Curie and elsewhere. Topics of particular interest to the team include the active mechanics of cells and tissues and the role of non-equilibrium processes on the inner organization and dynamics of cells, in particular that of intracellular organelles and protein clusters.
Research Interest
Soft biological matter
Active gels
Membrane systems
Active mechanics of cells and tissues
Membrane-cytoskeleton interactions
Cell motility
Spatio-temporal organisation of living cells
Spatio-temporal organisation of living cells
Clustering and segregation in non-equilibrium systems
Dynamics of membrane-bound cellular organelles
Cell homeostasis, Control
Osmotic regulation
Mechanical homeostasis of cellular membranes
Publications clés
Année de publication : 2019
Simon C*, Kusters R*, Caorsi V*, Allard A, Abou-Ghali M, Manzi J, Di Cicco A, Lévy D, Lenz M, Joanny J-F, Campillo C, Plastino J, Sens P*, Sykes C* (2019 Mar 18)
Polarization of cells and soft objects driven by mechanical interactions: consequences for migration and chemotaxis.
Physical review. E, Statistical, nonlinear, and soft matter physics
: 022720
Année de publication : 2010
Bidisha Sinha, Darius Köster, Richard Ruez, Pauline Gonnord, Michele Bastiani, Daniel Abankwa, Radu V Stan, Gillian Butler-Browne, Benoit Vedie, Ludger Johannes, Nobuhiro Morone, Robert G Parton, Graça Raposo, Pierre Sens, Christophe Lamaze, Pierre Nassoy (2010 Jan 7)
Cells respond to mechanical stress by rapid disassembly of caveolae.