Pierre Sens


Pierre Sens Chef d'équipe Directeur de Recherche CNRS

My goal is to use tools of theoretical Physics to study biological systems in a broad range of length and time scales

See my website

The main focus of the research done in my team at Institut curie is the use of theoretical approaches based on Physics to understand the organization and dynamics of living matter, particularly at the level of biological cells and cellular tissues. We are developing theoretical models using methods of statistical physics, non-linear dynamics and soft-matter physics, to improve our understanding of the principles governing the organization of cellular processes.

An important aspect of our work is to work in close collaboration with experimental physicists and biologists, at Institut Curie and elsewhere. Topics of particular interest to the team include the active mechanics of cells and tissues and the role of non-equilibrium processes on the inner organization and dynamics of cells, in particular that of intracellular organelles and protein clusters.

Research Interest

Soft biological matter

  • Active gels
  • Membrane systems

Active mechanics of cells and tissues

  • Membrane-cytoskeleton interactions
  • Cell motility

Spatio-temporal organisation of living cells

  • Spatio-temporal organisation of living cells
  • Clustering and segregation in non-equilibrium systems
  • Dynamics of membrane-bound cellular organelles

Cell homeostasis, Control

  • Osmotic regulation
  • Mechanical homeostasis of cellular membranes

Publications clés

Année de publication : 2019

Simon C*, Kusters R*, Caorsi V*, Allard A, Abou-Ghali M, Manzi J, Di Cicco A, Lévy D, Lenz M, Joanny J-F, Campillo C, Plastino J, Sens P*, Sykes C* (2019 Mar 18)

Actin dynamics drive cell-like membrane deformation

Nature Physics : DOI : 10.1038/s41567-019-0464-1

Année de publication : 2016

Vincent Nier, Shreyansh Jain, Chwee Teck Lim, Shuji Ishihara, Benoit Ladoux, Philippe Marcq (2016 Apr 14)

Inference of Internal Stress in a Cell Monolayer.

Biophysical journal : 1625-35 : DOI : 10.1016/j.bpj.2016.03.002

Année de publication : 2015

Pierre Sens, Julie Plastino (2015 Jun 11)

Membrane tension and cytoskeleton organization in cell motility.

Journal of physics. Condensed matter : an Institute of Physics journal : 273103 : DOI : 10.1088/0953-8984/27/27/273103
Ricard Alert, Jaume Casademunt, Jan Brugués, Pierre Sens (2015 Apr 23)

Model for probing membrane-cortex adhesion by micropipette aspiration and fluctuation spectroscopy.

Biophysical journal : 1878-86 : DOI : 10.1016/j.bpj.2015.02.027
M Leoni, P Sens (2015 Mar 14)

Polarization of cells and soft objects driven by mechanical interactions: consequences for migration and chemotaxis.

Physical review. E, Statistical, nonlinear, and soft matter physics : 022720

Année de publication : 2010

Bidisha Sinha, Darius Köster, Richard Ruez, Pauline Gonnord, Michele Bastiani, Daniel Abankwa, Radu V Stan, Gillian Butler-Browne, Benoit Vedie, Ludger Johannes, Nobuhiro Morone, Robert G Parton, Graça Raposo, Pierre Sens, Christophe Lamaze, Pierre Nassoy (2010 Jan 7)

Cells respond to mechanical stress by rapid disassembly of caveolae.

Cell : 402-13 : DOI : 10.1016/j.cell.2010.12.031