Nicolas Manel, PhD

Nicolas Manel

Nicolas Manel Chef d'équipe, DR2 INSERM

Publications clés

Année de publication : 2019

Matthieu Gratia, Mathieu P Rodero, Cécile Conrad, Elias Bou Samra, Mathieu Maurin, Gillian I Rice, Darragh Duffy, Patrick Revy, Florence Petit, Russell C Dale, Yanick J Crow, Mounira Amor-Gueret, Nicolas Manel (2019 Apr 1)

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.

The Journal of experimental medicine : DOI : jem.20181329
Matteo Gentili, Xavier Lahaye, Francesca Nadalin, Guilherme P F Nader, Emilia Puig Lombardi, Solène Herve, Nilushi S De Silva, Derek C Rookhuizen, Elina Zueva, Christel Goudot, Mathieu Maurin, Aurore Bochnakian, Sebastian Amigorena, Matthieu Piel, Daniele Fachinetti, Arturo Londoño-Vallejo, Nicolas Manel (2019 Mar 28)

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.

Cell reports : 3798 : DOI : S2211-1247(19)30365-1

Année de publication : 2018

Xavier Lahaye, Matteo Gentili, Aymeric Silvin, Cécile Conrad, Léa Picard, Mabel Jouve, Elina Zueva, Mathieu Maurin, Francesca Nadalin, Gavin J Knott, Baoyu Zhao, Fenglei Du, Marlène Rio, Jeanne Amiel, Archa H Fox, Pingwei Li, Lucie Etienne, Charles S Bond, Laurence Colleaux, Nicolas Manel (2018 Oct 2)

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation.

Cell : 488-501.e22 : DOI : S0092-8674(18)31163-2
SAEZ-CIRION Asier, MANEL Nicolas (2018 Jan 12)

Immune Responses to Retroviruses

Annual Review of ImmunologyAnnual Review of Immunology : DOI : 10.1146/annurev-immunol-051116-052155

Année de publication : 2017

SILVIN Aymeric, YU Chun, LAHAYE Xavier, IMPERATORE Francesco, BRAULT Jean-Baptiste, CARDINAUD Sylvain, BECKER Christian, KWAN Wing-Hong, CONRAD Cécile, MAURIN Mathieu, GOUDOT Christel, MARQUES-LADEIRA Santy, WANG Yuanyuan, PASCUAL Virginia, ANGUIANO Esperanza, ALBRECHT Randy, IANNACONE Matteo, GARCÍA-SASTRE Adolfo, GOUD Bruno, DALOD Marc, MORIS Arnaud, MERAD Miriam, PALUCKA Karolina, MANEL Nicolas (2017 Jul 7)

Constitutive resistance to viral infection in human CD141+ dendritic cells

Science Immunology : DOI : 10.1126/sciimmunol.aai8071
Cerboni S, Jeremiah N, Gentili M, Gehrmann U, Conrad C, Stolzenberg MC, Picard C, Neven B, Fischer A, Amigorena S, Rieux-Laucat F, Manel N (2017 May 8)

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

The Journal of Experimental Medicine : DOI : 10.1084/jem.20161674

Année de publication : 2016

M Raab, M Gentili, H de Belly, H R Thiam, P Vargas, A J Jimenez, F Lautenschlaeger, Raphaël Voituriez, A M Lennon-Duménil, N Manel, M Piel (2016 Apr 15)

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Science (New York, N.Y.) : DOI : 10.1126/science.aad7611

Année de publication : 2015

Gentili M, Kowal 1, Tkach M, Satoh T, Lahaye X, Conrad C, Boyron M, Lombard B, Durand S, Kroemer G, Loew D, Dalod M, Théry C, Manel N. (2015 Jul 30)

Transmission of innate immune signaling by packaging of cGAMP in viral particles.

Science : DOI : 10.1126/science.aab3628

Année de publication : 2014

Maxime Touzot, Maximilien Grandclaudon, Antonio Cappuccio, Takeshi Satoh, Carolina Martinez-Cingolani, Nicolas Servant, Nicolas Manel, Vassili Soumelis (2014 May 29)

Combinatorial flexibility of cytokine function during human T helper cell differentiation.

Nature communications : 3987 : DOI : 10.1038/ncomms4987

Année de publication : 2013

Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Cécile Conrad, Ilse Hurbain, Ahmed El Marjou, Christine Lacabaratz, Jean-Daniel Lelièvre, Nicolas Manel (2013 Sep 6)

The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.

Immunity : 1132-42 : DOI : 10.1016/j.immuni.2013.11.002

Année de publication : 2011

Nicolas Manel, Dan R Littman (2011 Jul 14)

Hiding in plain sight: how HIV evades innate immune responses.

Cell : 271-4 : DOI : 10.1016/j.cell.2011.09.010