Edith Heard, PhD

Photo_Edith_Heard-1

Edith Heard Chef d'équipe Tél :

  • 2019: Appointed Director General of EMBL.
  • 2012: Professor, Collège de France - chair "Epigenetic and cellular memory".
  • Since Jan 2010: Direction of the Genetics and Developmental Biology unit, UMR3215 CNRS / U934 INSERM, Institut Curie, Paris.
  • 2008-2010: Co-direction with Prof S. Artavanis-Tsakonas of the Genetics and Developmental Biology unit, UMR3215 CNRS / U934 INSERM, Institut Curie, Paris.
  • 2008: Director of Research 1st class (DR1) with the CNRS.
  • 2006-2008: Senior Team leader, Nuclear Dynamics and Genome Plasticity unit, UMR218 CNRS (directed by G. Almouzni), Institut Curie, Paris.
  • 2004: Director of Research 2nd class (DR2) with the CNRS.
  • 2001-2006: Young Team leader (CNRS ATIPE), Nuclear Dynamics and Genome Plasticity unit, UMR218 CNRS (directed by G. Almouzni), Institut Curie, Paris.
  • 2000-2001: Visiting scientist in Dr. David Spector's laboratory, Cold Spring Harbor, NY, USA.
  • 1993-2000: CNRS staff scientist in the laboratory of Dr. Philip Avner, Pasteur Institute, Paris.
  • 1990-1993: Postdoctoral fellow in the laboratory of Dr. Philip Avner, Pasteur Institute, Paris.
  • 1986-1990: Ph.D supervised by Dr. Mike Fried, Imperial Cancer Research Fund laboratory, London, UK.
  • 1986: B.A. in Natural Sciences (Genetics) from Cambridge University, UK.

Publications clés

Année de publication : 2018

Żylicz Jan Jakub, Bousard Aurélie, Žumer Kristina, Dossin François, Mohammad Eusra, Teixiera da Rocha Simão, Schwalb Björn, Syx Laurène, Dingli Florent, Loew Damarys, Cramer Patrick, Heard Edith (2018 Dec 21)

The Implication of Early Chromatin Changes in X Chromosome Inactivation

Cell : 176 : 1-16 : DOI : 10.1016/j.cell.2018.11.041

Année de publication : 2017

Maud Borensztein, Laurène Syx, Katia Ancelin, Patricia Diabangouaya, Christel Picard, Tao Liu, Jun-Bin Liang, Ivaylo Vassilev, Rafael Galupa, Nicolas Servant, Emmanuel Barillot, Azim Surani, Chong-Jian Chen, Edith Heard (2017 Jan 31)

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.

Nature structural & molecular biology : DOI : 10.1038/nsmb.3365

Année de publication : 2016

Luca Giorgetti, Bryan R Lajoie, Ava C Carter, Mikael Attia, Ye Zhan, Jin Xu, Chong Jian Chen, Noam Kaplan, Howard Y Chang, Edith Heard, Job Dekker (2016 Jul 21)

Structural organization of the inactive X chromosome in the mouse.

Nature : DOI : 10.1038/nature18589

Année de publication : 2015

Serena Sanulli, Neil Justin, Aurélie Teissandier, Katia Ancelin, Manuela Portoso, Matthieu Caron, Audrey Michaud, Berangère Lombard, Simao T da Rocha, John Offer, Damarys Loew, Nicolas Servant, Michel Wassef, Fabienne Burlina, Steve J Gamblin, Edith Heard, Raphaël Margueron (2015 Mar 5)

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

Molecular cell : 769-83 : DOI : 10.1016/j.molcel.2014.12.020
Servant N., Varoquaux N., Lajoie B.R., Viara E., Chen C.J., Vert J.P., Heard E., Dekker J., Barillot E. (2015 Jan 1)

HiC-Pro: an optimized and flexible pipeline for Hi-C data processing

Genome biology : 16 : 1

Année de publication : 2014

Luca Giorgetti, Rafael Galupa, Elphège P Nora, Tristan Piolot, France Lam, Job Dekker, Guido Tiana, Edith Heard (2014 May 1)

Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription.

Cell : 950-63 : DOI : 10.1016/j.cell.2014.03.025
Anne-Valerie Gendrel, Mikael Attia, Chong-Jian Chen, Patricia Diabangouaya, Nicolas Servant, Emmanuel Barillot, Edith Heard (2014 Feb 24)

Developmental dynamics and disease potential of random monoallelic gene expression.

Developmental cell : 366-80 : DOI : 10.1016/j.devcel.2014.01.016
Edda G Schulz, Johannes Meisig, Tomonori Nakamura, Ikuhiro Okamoto, Anja Sieber, Christel Picard, Maud Borensztein, Mitinori Saitou, Nils Blüthgen, Edith Heard (2014 Feb 6)

The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network.

Cell stem cell : 203-16 : DOI : 10.1016/j.stem.2013.11.022

Année de publication : 2011

Martin Escamilla-Del-Arenal, Simao Teixeira da Rocha, Edith Heard (2011 May 1)

Evolutionary diversity and developmental regulation of X-chromosome inactivation.

Human genetics : 307-27 : DOI : 10.1007/s00439-011-1029-2