Edith Heard, PhD

Photo_Edith_Heard-1

Edith Heard Directeur de l'Unité Chef d'équipe Tél :

  • 2012: Professor, Collège de France - chair "Epigenetic and cellular memory".
  • Since Jan 2010: Direction of the Genetics and Developmental Biology unit, UMR3215 CNRS / U934 INSERM, Institut Curie, Paris.
  • 2008-2010: Co-direction with Prof S. Artavanis-Tsakonas of the Genetics and Developmental Biology unit, UMR3215 CNRS / U934 INSERM, Institut Curie, Paris.
  • 2008: Director of Research 1st class (DR1) with the CNRS.
  • 2006-2008: Senior Team leader, Nuclear Dynamics and Genome Plasticity unit, UMR218 CNRS (directed by G. Almouzni), Institut Curie, Paris.
  • 2004: Director of Research 2nd class (DR2) with the CNRS.
  • 2001-2006: Young Team leader (CNRS ATIPE), Nuclear Dynamics and Genome Plasticity unit, UMR218 CNRS (directed by G. Almouzni), Institut Curie, Paris.
  • 2000-2001: Visiting scientist in Dr. David Spector's laboratory, Cold Spring Harbor, NY, USA.
  • 1993-2000: CNRS staff scientist in the laboratory of Dr. Philip Avner, Pasteur Institute, Paris.
  • 1990-1993: Postdoctoral fellow in the laboratory of Dr. Philip Avner, Pasteur Institute, Paris.
  • 1986-1990: Ph.D supervised by Dr. Mike Fried, Imperial Cancer Research Fund laboratory, London, UK.
  • 1986: B.A. in Natural Sciences (Genetics) from Cambridge University, UK.

Publications clés

Année de publication : 2017

Maud Borensztein, Laurène Syx, Katia Ancelin, Patricia Diabangouaya, Christel Picard, Tao Liu, Jun-Bin Liang, Ivaylo Vassilev, Rafael Galupa, Nicolas Servant, Emmanuel Barillot, Azim Surani, Chong-Jian Chen, Edith Heard (2017 Jan 31)

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.

Nature structural & molecular biology : DOI : 10.1038/nsmb.3365

Année de publication : 2016

Luca Giorgetti, Bryan R Lajoie, Ava C Carter, Mikael Attia, Ye Zhan, Jin Xu, Chong Jian Chen, Noam Kaplan, Howard Y Chang, Edith Heard, Job Dekker (2016 Jul 21)

Structural organization of the inactive X chromosome in the mouse.

Nature : DOI : 10.1038/nature18589

Année de publication : 2015

Serena Sanulli, Neil Justin, Aurélie Teissandier, Katia Ancelin, Manuela Portoso, Matthieu Caron, Audrey Michaud, Berangère Lombard, Simao T da Rocha, John Offer, Damarys Loew, Nicolas Servant, Michel Wassef, Fabienne Burlina, Steve J Gamblin, Edith Heard, Raphaël Margueron (2015 Mar 5)

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

Molecular cell : 769-83 : DOI : 10.1016/j.molcel.2014.12.020
Servant N., Varoquaux N., Lajoie B.R., Viara E., Chen C.J., Vert J.P., Heard E., Dekker J., Barillot E. (2015 Jan 1)

HiC-Pro: an optimized and flexible pipeline for Hi-C data processing

Genome biology : 16 : 1

Année de publication : 2014

Luca Giorgetti, Rafael Galupa, Elphège P Nora, Tristan Piolot, France Lam, Job Dekker, Guido Tiana, Edith Heard (2014 May 1)

Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription.

Cell : 950-63 : DOI : 10.1016/j.cell.2014.03.025
Anne-Valerie Gendrel, Mikael Attia, Chong-Jian Chen, Patricia Diabangouaya, Nicolas Servant, Emmanuel Barillot, Edith Heard (2014 Feb 24)

Developmental dynamics and disease potential of random monoallelic gene expression.

Developmental cell : 366-80 : DOI : 10.1016/j.devcel.2014.01.016
Edda G Schulz, Johannes Meisig, Tomonori Nakamura, Ikuhiro Okamoto, Anja Sieber, Christel Picard, Maud Borensztein, Mitinori Saitou, Nils Blüthgen, Edith Heard (2014 Feb 6)

The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network.

Cell stem cell : 203-16 : DOI : 10.1016/j.stem.2013.11.022

Année de publication : 2011

Martin Escamilla-Del-Arenal, Simao Teixeira da Rocha, Edith Heard (2011 May 1)

Evolutionary diversity and developmental regulation of X-chromosome inactivation.

Human genetics : 307-27 : DOI : 10.1007/s00439-011-1029-2