Daniela Verga

Daniela Verga

Daniela Verga Chargée de recherche CNRS Tél :

Daniela Verga holds a PhD in Organic chemistry (2010) on the synthesis of photoactivatable DNA cross-linkers (supervisor: M. Freccero, University of Pavia). During her PhD, she worked at the Georgia Institute of Technology in Gary B. Schuster’s lab to study photodamages induced on DNA and biochemistry. She was Postdoc at the Institut Curie in M.-P. Teulade-Fichou’s group (2011-12) where she worked on the synthesis of covalent G4 DNA binding compounds and their biochemical application and then she moved to Germany as a Postdoc awarded with a von Humboldt fellowship (2013-15) working in the field of chemical biology in A. Marx’s group (Konstanz, Germany), where she deepened her knowledge in DNA biochemistry and biology.

Since December 2015, Dr. Verga is a young permanent researcher (Chargée de recherche CNRS, CRCN) in the Chemistry and Modelling for the Biology of Cancer (CMBC) research unit at the Institut Curie (UMR9187-U1196 headed by M.-P. Teulade-Fichou). More precisely, she works in the "Probes and Drugs of Nucleic acids Secondary Structures" team, directed by M.-P. Teulade-Fichou, where she leads a small group (2 PhD students, working at the interface between chemistry, biochemistry, and biology, and 1 technical staff (IE) expert in organic synthesis) working on the synthesis of selective non-alkylating and alkylating G4 ligands with the aim to employ them to unlock biological processes.

In 2018 she was awarded with a young researcher grant funded by the Agence National de la Recherche (JCJC ANR) to develop her own research.

Publications clés

Année de publication : 2020

Yu Luo, Anton Granzhan, Daniela Verga, Jean-Louis Mergny (2020 Dec 28)

FRET-MC: A fluorescence melting competition assay for studying G4 structures in vitro.

Biopolymers : Early view : bip23415 : DOI : 10.1002/bip.23415
Václav Brázda, Yu Luo, Martin Bartas, Patrik Kaura, Otilia Porubiaková, Jiří Šťastný, Petr Pečinka, Daniela Verga, Violette Da Cunha, Tomio S Takahashi, Patrick Forterre, Hannu Myllykallio, Miroslav Fojta, Jean-Louis Mergny (2020 Sep 24)

G-Quadruplexes in the Archaea Domain.

Biomolecules : 10 : 1349 : DOI : 10.3390/biom10091349

Année de publication : 2019

Emilia Puig Lombardi, Allyson Holmes, Daniela Verga, Marie-Paule Teulade-Fichou, Alain Nicolas, Arturo Londoño-Vallejo (2019 Jul 9)

Thermodynamically stable and genetically unstable G-quadruplexes are depleted in genomes across species.

Nucleic acids research : 47 : 6098-6113 : DOI : 10.1093/nar/gkz463
Paul D., Marchand A., Verga D., Bombard S., Teulade-Fichou M.P., Rosu F., Gabelica V. (2019 Feb 28)

Probing Ligand and Cation Binding Sites in G-Quadruplex Nucleic Acids by Mass Spectrometry and Electron Photodetachment Dissociation Sequencing

Analyst : 144 : 3518-3524 : DOI : 10.1039/C9AN00398C
Delphine Naud-Martin, Corinne Landras-Guetta, Daniela Verga, Deepanjan Ghosh, Sylvain Achelle, Florence Mahuteau-Betzer, Sophie Bombard, Marie-Paule Teulade-Fichou (2019 Jan 26)

Selectivity of Terpyridine Platinum Anticancer Drugs for G-quadruplex DNA.

Molecules (Basel, Switzerland) : 24 : 404 : DOI : 10.3390/molecules24030404

Année de publication : 2018

Verga D., Nguyen C.H., Dakir M., Coll J.L., Teulade-Fichou M.P., Molla A. (2018 Nov 20)

Polyheteroaryl Oxazole/Pyridine-based compounds selected in vitro as G-quadruplex ligands inhibit Rock kinase and exhibit antiproliferative activity

Journal of Medicinal Chemistry : 61 : 10502-10518 : DOI : 10.1021/acs.jmedchem.8b01023
Filippo Doria, Valentina Pirota, Michele Petenzi, Marie-Paule Teulade-Fichou, Daniela Verga, Mauro Freccero (2018 Aug 30)

Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding.

Molecules (Basel, Switzerland) : 23 : 2162 : DOI : 10.3390/molecules23092162

Année de publication : 2017

Verga D., Hamon F., Nicoleau C., Guetta C., Wu T.-D., Guerquin-Kern J.-L., Marco S. & Teulade-Fichou M.-P. (2017 Jul 27)

Chemical Imaging by NanoSIMS Provides High- Resolution Localization of the G-Quadruplex Interactive Drug (Br)-PhenDC3 on Human Chromosomes

Journal of Molecular Biology and Molecular Imaging : 4 : 1029

Année de publication : 2014

Daniela Verga, Florian Hamon, Florent Poyer, Sophie Bombard, Marie-Paule Teulade-Fichou (2014 Jan 20)

Photo-cross-linking probes for trapping G-quadruplex DNA.

Angewandte Chemie (International ed. in English) : 53 : 994-998 : DOI : 10.1002/anie.201307413

Année de publication : 2012

Michele Petenzi, Daniela Verga, Eric Largy, Florian Hamon, Filippo Doria, Marie-Paule Teulade-Fichou, Aurore Guédin, Jean-Louis Mergny, Mariella Mella, Mauro Freccero (2012 Sep 22)

Cationic pentaheteroaryls as selective G-quadruplex ligands by solvent-free microwave-assisted synthesis.

Chemistry A European Journal : 18 : 14487-14496 : DOI : 10.1002/chem.201202097
Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga, Marie-Paule Teulade-Fichou (2012 Aug 14)

Visualizing the quadruplex: from fluorescent ligands to light-up probes.

Topics in current chemistry : 330 : 111-77 : DOI : 10.1007/128_2012_346