Résidu tumoral et réponse au traitement


Année de publication : 2014

Sonia Baulies, Isabelle Melonio, Paul Fréneaux, Benoit Couturaud, Alfred Fitoussi, Roman Rouzier, Caroline Malhaire, Peter Mallon, Fabien Reyal (2014 Oct 8)

Skin lesions after prophylactic mastectomy and immediate reconstruction.

Plastic and reconstructive surgery. Global open : e82 : DOI : 10.1097/GOX.0000000000000009 En savoir plus

Metastatic breast carcinoma can mimic benign cutaneous lesions. Breast surgeons should be aware of skin manifestations to be able to distinguish them and set a proper therapeutic strategy. A clinical case of cutaneous lesion after breast cancer is presented. A 41-year-old woman with a history of left breast cancer underwent a prophylactic right nipple-sparing mastectomy with immediate breast implant reconstruction. After surgery, she attended our service due to a right periareolar rash resistant to medical treatment, accompanied by cutaneous induration and fixed axillary adenopathy. A differential diagnosis of skin metastases was considered. Cutaneous metastases should be the first diagnosis of skin lesions in oncological patients due to the implications in terms of treatment and prognosis. However, differential diagnoses have to be discussed.

Matahi Moarii, Alice Pinheiro, Brigitte Sigal-Zafrani, Alain Fourquet, Martial Caly, Nicolas Servant, Véronique Stoven, Jean-Philippe Vert, Fabien Reyal (2014 Aug 8)

Epigenomic alterations in breast carcinoma from primary tumor to locoregional recurrences.

PloS one : e103986 : DOI : 10.1371/journal.pone.0103986 En savoir plus

Epigenetic modifications such as aberrant DNA methylation has long been associated with tumorogenesis. Little is known, however, about how these modifications appear in cancer progression. Comparing the methylome of breast carcinomas and locoregional evolutions could shed light on this process.